General Information

  • ID:  hor005322
  • Uniprot ID:  P82972
  • Protein name:  Natriuretic peptide PNP
  • Gene name:  NA
  • Organism:  Pseudocerastes persicus (Persian horned viper) (False horned viper)
  • Family:  natriuretic peptide family
  • Source:  Animal
  • Expression:  Expressed by the venom gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Pseudocerastes (genus), Viperinae (subfamily), Viperidae (family), Colubroidea (superfamily), Serpentes (infraorder), Toxicofera, Episquamata, Unidentata, Bifurcata, Squamata (order), Lepidosauria (class), Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0048018 receptor ligand activity; GO:0090729 toxin activity
  • GO BP:  GO:0007165 signal transduction; GO:0008217 regulation of blood pressure; GO:0042311 vasodilation; GO:0044496 negative regulation of blood pressure in another organism; GO:0044505 positive regulation of G protein-coupled receptor activity in another organism; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GENEPPKKKAPDGCFGHKIDRIGSHSGLGCNKFKPGH
  • Length:  37(1-37)
  • Propeptide:  GENEPPKKKAPDGCFGHKIDRIGSHSGLGCNKFKPGH
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  16-16G->T: Does not affect blood pressure or diuresis; 18-18G->T: Does not affect blood pressure or diuresis; 21-21G->T: Does not affect blood pressure or diuresis; 23-23G->T: Does not affect blood pressure or diuresis; 24-26G->T: Does not affect blood pr

Activity

  • Function:  Increases urine flow and decreases blood pressure when administered to rats by intravenous injection. Inhibits thrombin-induced platelet aggregation. Stimulates cGMP production via the natriuretic peptide receptor-A (NPR1).
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  14-30
  • Structure ID:  AF-P82972-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P82972-F1.pdbhor005322_AF2.pdbhor005322_ESM.pdb

Physical Information

Mass: 458677 Formula: C171H268N54O50S2
Absent amino acids: MQTVWY Common amino acids: G
pI: 9.51 Basic residues: 10
Polar residues: 13 Hydrophobic residues: 6
Hydrophobicity: -119.19 Boman Index: -8167
Half-Life / Aliphatic Index: 30 hour Aliphatic Index: 34.32
Instability Index: 2363.78 Extinction Coefficient cystines: 125
Absorbance 280nm: 3.47

Literature

  • PubMed ID:  14741349
  • Title:  Functional and structural characterization of a novel member of the natriuretic family of peptides from the venom of Pseudocerastes persicus.
  • PubMed ID:  16515458
  • Title:   Structural and functional characterization of a mutant of Pseudocerastes persicus natriuretic peptide.